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St. Louis Cardinals Schedule, 2010
| Date | Time | Opponent | Location |
| Spring Training | |||
| 3/4/2010 | 12:10 PM | Cardinals at Mets | Tradition Field |
| 3/5/2010 | 12:05 PM | Mets at Cardinals | Roger Dean Stadium |
| 3/6/2010 | 12:05 PM | Cardinals at Marlins | Roger Dean Stadium |
| 3/7/2010 | 12:05 PM | Marlins at Cardinals | Roger Dean Stadium |
| 3/8/2010 | 12:05 PM | Cardinals at Red Sox | City of Palms Park |
| 3/9/2010 | 12:05 PM | Cardinals at Twins | Lee County Sports Complex - Hammond County Stadium |
| 3/10/2010 | 12:05 PM | Nationals at Cardinals | Roger Dean Stadium |
| 3/11/2010 | 12:05 PM | Cardinals at Marlins | Roger Dean Stadium |
| 3/12/2010 | 12:05 PM | Red Sox at Cardinals | Roger Dean Stadium |
| 3/13/2010 | 12:05 PM | Astros at Cardinals | Roger Dean Stadium |
| 3/14/2010 | 12:05 PM | Cardinals at Nationals | Space Coast Stadium |
| 3/15/2010 | 12:10 PM | Cardinals at Mets | Tradition Field |
| 3/16/2010 | 12:05 PM | Nationals at Cardinals | Roger Dean Stadium |
| 3/18/2010 | 12:05 PM | Braves at Cardinals | Roger Dean Stadium |
| 3/19/2010 | 12:05 PM | Cardinals at Marlins | Roger Dean Stadium |
| 3/19/2010 | 6:05 PM | Cardinals at Nationals | Space Coast Stadium |
| 3/20/2010 | 12:05 PM | Mets at Cardinals | Roger Dean Stadium |
| 3/21/2010 | 12:05 PM | Cardinals at Braves | Champion Stadium |
| 3/22/2010 | 12:05 PM | Cardinals at Astros | Osceola County Stadium |
| 3/24/2010 | 12:05 PM | Orioles at Cardinals | Roger Dean Stadium |
| 3/25/2010 | 12:05 PM | Mets at Cardinals | Roger Dean Stadium |
| 3/26/2010 | 12:05 PM | Cardinals at Nationals | Space Coast Stadium |
| 3/27/2010 | 12:05 PM | Marlins at Cardinals | Roger Dean Stadium |
| 3/28/2010 | 12:10 PM | Cardinals at Mets | Tradition Field |
| 3/29/2010 | 12:05 PM | Twins at Cardinals | Roger Dean Stadium |
| 3/30/2010 | 12:10 PM | Cardinals at Mets | Tradition Field |
| 3/31/2010 | 12:05 PM | Nationals at Cardinals | Roger Dean Stadium |
| 4/1/2010 | 11:05 AM | Marlins at Cardinals | Roger Dean Stadium |
| 4/2/2010 | 5:10 PM | Cardinals at Twins | Target Field |
| 4/3/2010 | 1:10 PM | Cardinals at Twins | Target Field |
| Regular Season Begins | |||
| 4/5/2010 | 12:10 PM | Cardinals at Reds | Great American Ball Park |
| 4/7/2010 | 6:10 PM | Cardinals at Reds | Great American Ball Park |
| 4/8/2010 | 11:35 AM | Cardinals at Reds | Great American Ball Park |
| 4/9/2010 | 7:10 PM | Cardinals at Brewers | Miller Park |
| 4/10/2010 | 2:10 PM | Cardinals at Brewers | Miller Park |
| 4/11/2010 | 7:05 PM | Cardinals at Brewers | Miller Park |
| 4/12/2010 | 3:15 PM | Astros at Cardinals | Busch Stadium |
| 4/14/2010 | 7:15 PM | Astros at Cardinals | Busch Stadium |
| 4/15/2010 | 12:40 PM | Astros at Cardinals | Busch Stadium |
| 4/16/2010 | 7:15 PM | Mets at Cardinals | Busch Stadium |
| 4/17/2010 | 3:10 PM | Mets at Cardinals | Busch Stadium |
| 4/18/2010 | 7:05 PM | Mets at Cardinals | Busch Stadium |
| 4/19/2010 | 8:40 PM | Cardinals at D-backs | Chase Field |
| 4/20/2010 | 8:40 PM | Cardinals at D-backs | Chase Field |
| 4/21/2010 | 8:40 PM | Cardinals at D-backs | Chase Field |
| 4/23/2010 | 9:15 PM | Cardinals at Giants | AT&T Park |
| 4/24/2010 | 8:05 PM | Cardinals at Giants | AT&T Park |
| 4/25/2010 | 3:05 PM | Cardinals at Giants | AT&T Park |
| 4/26/2010 | 7:15 PM | Braves at Cardinals | Busch Stadium |
| 4/27/2010 | 7:15 PM | Braves at Cardinals | Busch Stadium |
| 4/28/2010 | 7:15 PM | Braves at Cardinals | Busch Stadium |
| 4/29/2010 | 12:40 PM | Braves at Cardinals | Busch Stadium |
| 4/30/2010 | 7:15 PM | Reds at Cardinals | Busch Stadium |
| 5/1/2010 | 12:10 PM | Reds at Cardinals | Busch Stadium |
| 5/2/2010 | 1:15 PM | Reds at Cardinals | Busch Stadium |
| 5/3/2010 | 6:05 PM | Cardinals at Phillies | Citizens Bank Park |
| 5/4/2010 | 6:05 PM | Cardinals at Phillies | Citizens Bank Park |
| 5/5/2010 | 6:05 PM | Cardinals at Phillies | Citizens Bank Park |
| 5/6/2010 | 12:05 PM | Cardinals at Phillies | Citizens Bank Park |
| 5/7/2010 | 6:05 PM | Cardinals at Pirates | PNC Park |
| 5/8/2010 | 6:05 PM | Cardinals at Pirates | PNC Park |
| 5/9/2010 | 12:35 PM | Cardinals at Pirates | PNC Park |
| 5/11/2010 | 7:15 PM | Astros at Cardinals | Busch Stadium |
| 5/12/2010 | 7:15 PM | Astros at Cardinals | Busch Stadium |
| 5/13/2010 | 12:40 PM | Astros at Cardinals | Busch Stadium |
| 5/14/2010 | 6:10 PM | Cardinals at Reds | Great American Ball Park |
| 5/15/2010 | 6:10 PM | Cardinals at Reds | Great American Ball Park |
| 5/16/2010 | 12:10 PM | Cardinals at Reds | Great American Ball Park |
| 5/17/2010 | 7:15 PM | Nationals at Cardinals | Busch Stadium |
| 5/18/2010 | 7:15 PM | Nationals at Cardinals | Busch Stadium |
| 5/19/2010 | 7:15 PM | Marlins at Cardinals | Busch Stadium |
| 5/20/2010 | 12:40 PM | Marlins at Cardinals | Busch Stadium |
| 5/21/2010 | 7:15 PM | Angels at Cardinals | Busch Stadium |
| 5/22/2010 | 1:15 PM | Angels at Cardinals | Busch Stadium |
| 5/23/2010 | 1:15 PM | Angels at Cardinals | Busch Stadium |
| 5/25/2010 | 9:05 PM | Cardinals at Padres | PETCO Park |
| 5/26/2010 | 9:05 PM | Cardinals at Padres | PETCO Park |
| 5/27/2010 | 5:35 PM | Cardinals at Padres | PETCO Park |
| 5/28/2010 | 1:20 PM | Cardinals at Cubs | Wrigley Field |
| 5/29/2010 | 3:10 PM | Cardinals at Cubs | Wrigley Field |
| 5/30/2010 | 1:20 PM | Cardinals at Cubs | Wrigley Field |
| 5/31/2010 | 3:15 PM | Reds at Cardinals | Busch Stadium |
| 6/1/2010 | 7:15 PM | Reds at Cardinals | Busch Stadium |
| 6/2/2010 | 7:15 PM | Reds at Cardinals | Busch Stadium |
| 6/4/2010 | 7:15 PM | Brewers at Cardinals | Busch Stadium |
| 6/5/2010 | 3:10 PM | Brewers at Cardinals | Busch Stadium |
| 6/6/2010 | 1:15 PM | Brewers at Cardinals | Busch Stadium |
| 6/7/2010 | 9:10 PM | Cardinals at Dodgers | Dodger Stadium |
| 6/8/2010 | 9:10 PM | Cardinals at Dodgers | Dodger Stadium |
| 6/9/2010 | 9:10 PM | Cardinals at Dodgers | Dodger Stadium |
| 6/11/2010 | 8:40 PM | Cardinals at D-backs | Chase Field |
| 6/12/2010 | 7:10 PM | Cardinals at D-backs | Chase Field |
| 6/13/2010 | 3:10 PM | Cardinals at D-backs | Chase Field |
| 6/14/2010 | 7:15 PM | Mariners at Cardinals | Busch Stadium |
| 6/15/2010 | 7:15 PM | Mariners at Cardinals | Busch Stadium |
| 6/16/2010 | 7:15 PM | Mariners at Cardinals | Busch Stadium |
| 6/18/2010 | 7:15 PM | Athletics at Cardinals | Busch Stadium |
| 6/19/2010 | 3:33 AM | Athletics at Cardinals | Busch Stadium |
| 6/20/2010 | 1:15 PM | Athletics at Cardinals | Busch Stadium |
| 6/22/2010 | 6:07 PM | Cardinals at Blue Jays | Rogers Centre |
| 6/23/2010 | 6:07 PM | Cardinals at Blue Jays | Rogers Centre |
| 6/24/2010 | 6:07 PM | Cardinals at Blue Jays | Rogers Centre |
| 6/25/2010 | 7:10 PM | Cardinals at Royals | Kauffman Stadium |
| 6/26/2010 | 1:10 PM | Cardinals at Royals | Kauffman Stadium |
| 6/27/2010 | 1:10 PM | Cardinals at Royals | Kauffman Stadium |
| 6/28/2010 | 7:15 PM | D-backs at Cardinals | Busch Stadium |
| 6/29/2010 | 7:15 PM | D-backs at Cardinals | Busch Stadium |
| 6/30/2010 | 1:15 PM | D-backs at Cardinals | Busch Stadium |
| 7/1/2010 | 7:15 PM | Brewers at Cardinals | Busch Stadium |
| 7/2/2010 | 7:15 PM | Brewers at Cardinals | Busch Stadium |
| 7/3/2010 | 3:10 PM | Brewers at Cardinals | Busch Stadium |
| 7/4/2010 | 1:15 PM | Brewers at Cardinals | Busch Stadium |
| 7/6/2010 | 7:40 PM | Cardinals at Rockies | Coors Field |
| 7/7/2010 | 7:40 PM | Cardinals at Rockies | Coors Field |
| 7/8/2010 | 2:10 PM | Cardinals at Rockies | Coors Field |
| 7/9/2010 | 7:05 PM | Cardinals at Astros | Minute Maid Park |
| 7/10/2010 | 6:05 PM | Cardinals at Astros | Minute Maid Park |
| 7/11/2010 | 1:05 PM | Cardinals at Astros | Minute Maid Park |
| 7/13/2010 | 3:33 AM | NL All-Stars at AL All-Stars |
Angel Stadium of Anaheim |
| 7/15/2010 | 7:15 PM | Dodgers at Cardinals | Busch Stadium |
| 7/16/2010 | 7:15 PM | Dodgers at Cardinals | Busch Stadium |
| 7/17/2010 | 3:10 PM | Dodgers at Cardinals | Busch Stadium |
| 7/18/2010 | 1:15 PM | Dodgers at Cardinals | Busch Stadium |
| 7/19/2010 | 7:15 PM | Phillies at Cardinals | Busch Stadium |
| 7/20/2010 | 7:15 PM | Phillies at Cardinals | Busch Stadium |
| 7/21/2010 | 7:15 PM | Phillies at Cardinals | Busch Stadium |
| 7/22/2010 | 1:15 PM | Phillies at Cardinals | Busch Stadium |
| 7/23/2010 | 1:20 PM | Cardinals at Cubs | Wrigley Field |
| 7/24/2010 | 12:05 PM | Cardinals at Cubs | Wrigley Field |
| 7/25/2010 | 3:33 AM | Cardinals at Cubs | Wrigley Field |
| 7/27/2010 | 6:10 PM | Cardinals at Mets | Citi Field |
| 7/28/2010 | 6:10 PM | Cardinals at Mets | Citi Field |
| 7/29/2010 | 11:10 AM | Cardinals at Mets | Citi Field |
| 7/30/2010 | 7:15 PM | Pirates at Cardinals | Busch Stadium |
| 7/31/2010 | 6:15 PM | Pirates at Cardinals | Busch Stadium |
| 8/1/2010 | 1:15 PM | Pirates at Cardinals | Busch Stadium |
| 8/2/2010 | 7:15 PM | Astros at Cardinals | Busch Stadium |
| 8/3/2010 | 7:15 PM | Astros at Cardinals | Busch Stadium |
| 8/4/2010 | 7:15 PM | Astros at Cardinals | Busch Stadium |
| 8/6/2010 | 6:10 PM | Cardinals at Marlins | Sun Life Stadium |
| 8/7/2010 | 6:10 PM | Cardinals at Marlins | Sun Life Stadium |
| 8/8/2010 | 12:10 PM | Cardinals at Marlins | Sun Life Stadium |
| 8/9/2010 | 6:10 PM | Cardinals at Reds | Great American Ball Park |
| 8/10/2010 | 6:10 PM | Cardinals at Reds | Great American Ball Park |
| 8/11/2010 | 11:35 AM | Cardinals at Reds | Great American Ball Park |
| 8/13/2010 | 7:15 PM | Cubs at Cardinals | Busch Stadium |
| 8/14/2010 | 3:10 PM | Cubs at Cardinals | Busch Stadium |
| 8/15/2010 | 1:15 PM | Cubs at Cardinals | Busch Stadium |
| 8/17/2010 | 7:15 PM | Brewers at Cardinals | Busch Stadium |
| 8/18/2010 | 1:15 PM | Brewers at Cardinals | Busch Stadium |
| 8/20/2010 | 7:15 PM | Giants at Cardinals | Busch Stadium |
| 8/21/2010 | 6:15 PM | Giants at Cardinals | Busch Stadium |
| 8/22/2010 | 1:15 PM | Giants at Cardinals | Busch Stadium |
| 8/23/2010 | 6:05 PM | Cardinals at Pirates | PNC Park |
| 8/24/2010 | 6:05 PM | Cardinals at Pirates | PNC Park |
| 8/25/2010 | 6:05 PM | Cardinals at Pirates | PNC Park |
| 8/26/2010 | 6:05 PM | Cardinals at Nationals | Nationals Park |
| 8/27/2010 | 6:05 PM | Cardinals at Nationals | Nationals Park |
| 8/28/2010 | 6:05 PM | Cardinals at Nationals | Nationals Park |
| 8/29/2010 | 12:35 PM | Cardinals at Nationals | Nationals Park |
| 8/30/2010 | 7:05 PM | Cardinals at Astros | Minute Maid Park |
| 8/31/2010 | 7:05 PM | Cardinals at Astros | Minute Maid Park |
| 9/1/2010 | 1:05 PM | Cardinals at Astros | Minute Maid Park |
| 9/3/2010 | 7:15 PM | Reds at Cardinals | Busch Stadium |
| 9/4/2010 | 6:15 PM | Reds at Cardinals | Busch Stadium |
| 9/5/2010 | 1:15 PM | Reds at Cardinals | Busch Stadium |
| 9/6/2010 | 1:10 PM | Cardinals at Brewers | Miller Park |
| 9/7/2010 | 7:10 PM | Cardinals at Brewers | Miller Park |
| 9/8/2010 | 7:10 PM | Cardinals at Brewers | Miller Park |
| 9/9/2010 | 6:10 PM | Cardinals at Braves | Turner Field |
| 9/10/2010 | 6:35 PM | Cardinals at Braves | Turner Field |
| 9/11/2010 | 3:10 PM | Cardinals at Braves | Turner Field |
| 9/12/2010 | 12:35 PM | Cardinals at Braves | Turner Field |
| 9/13/2010 | 7:15 PM | Cubs at Cardinals | Busch Stadium |
| 9/14/2010 | 7:15 PM | Cubs at Cardinals | Busch Stadium |
| 9/15/2010 | 7:15 PM | Cubs at Cardinals | Busch Stadium |
| 9/16/2010 | 7:15 PM | Padres at Cardinals | Busch Stadium |
| 9/17/2010 | 7:15 PM | Padres at Cardinals | Busch Stadium |
| 9/18/2010 | 6:15 PM | Padres at Cardinals | Busch Stadium |
| 9/19/2010 | 1:15 PM | Padres at Cardinals | Busch Stadium |
| 9/21/2010 | 6:05 PM | Cardinals at Pirates | PNC Park |
| 9/22/2010 | 6:05 PM | Cardinals at Pirates | PNC Park |
| 9/23/2010 | 11:35 AM | Cardinals at Pirates | PNC Park |
| 9/24/2010 | 1:20 PM | Cardinals at Cubs | Wrigley Field |
| 9/25/2010 | 3:33 AM | Cardinals at Cubs | Wrigley Field |
| 9/26/2010 | 3:33 AM | Cardinals at Cubs | Wrigley Field |
| 9/27/2010 | 7:15 PM | Pirates at Cardinals | Busch Stadium |
| 9/28/2010 | 7:15 PM | Pirates at Cardinals | Busch Stadium |
| 9/29/2010 | 12:40 PM | Pirates at Cardinals | Busch Stadium |
| 9/30/2010 | 7:15 PM | Rockies at Cardinals | Busch Stadium |
| 10/1/2010 | 7:15 PM | Rockies at Cardinals | Busch Stadium |
| 10/2/2010 | 12:10 PM | Rockies at Cardinals | Busch Stadium |
| 10/3/2010 | 1:15 PM | Rockies at Cardinals | Busch Stadium |
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