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Baltimore Orioles Schedule, 2010
| Date | Time | Opponent | Location |
| Spring Training | |||
| 3/3/2010 | 1:05 PM | Rays at Orioles | Ed Smith Stadium |
| 3/4/2010 | 1:05 PM | Orioles at Rays | Charlotte County Stadium |
| 3/5/2010 | 7:05 PM | Pirates at Orioles | Ed Smith Stadium |
| 3/6/2010 | 1:05 PM | Orioles at Tigers | Joker Marchant Stadium |
| 3/7/2010 | 1:05 PM | Red Sox at Orioles | Ed Smith Stadium |
| 3/8/2010 | 1:05 PM | Twins at Orioles | Ed Smith Stadium |
| 3/9/2010 | 1:05 PM | Rays at Orioles | Ed Smith Stadium |
| 3/10/2010 | 7:05 PM | Orioles at Pirates | McKechnie Field |
| 3/11/2010 | 7:05 PM | Orioles at Twins | Lee County Sports Complex - Hammond County Stadium |
| 3/12/2010 | 1:05 PM | Marlins at Orioles | Ed Smith Stadium |
| 3/13/2010 | 1:05 PM | Orioles at Yankees | George M. Steinbrenner Field |
| 3/14/2010 | 1:05 PM | Phillies at Orioles | Ed Smith Stadium |
| 3/15/2010 | 1:05 PM | Orioles at Red Sox | City of Palms Park |
| 3/16/2010 | 1:05 PM | Orioles at Twins | Lee County Sports Complex - Hammond County Stadium |
| 3/17/2010 | 1:05 PM | Blue Jays at Orioles | Ed Smith Stadium |
| 3/18/2010 | 1:05 PM | Orioles at Blue Jays | Dunedin Stadium |
| 3/19/2010 | 7:05 PM | Orioles at Phillies | Bright House Networks Field |
| 3/20/2010 | 1:05 PM | Orioles at Red Sox | City of Palms Park |
| 3/20/2010 | 1:05 PM | Pirates at Orioles | Ed Smith Stadium |
| 3/21/2010 | 1:05 PM | Orioles at Phillies | Bright House Networks Field |
| 3/23/2010 | 1:05 PM | Orioles at Marlins | Roger Dean Stadium |
| 3/24/2010 | 1:05 PM | Orioles at Cardinals | Roger Dean Stadium |
| 3/25/2010 | 1:05 PM | Yankees at Orioles | Ed Smith Stadium |
| 3/26/2010 | 7:05 PM | Twins at Orioles | Ed Smith Stadium |
| 3/27/2010 | 1:05 PM | Red Sox at Orioles | Ed Smith Stadium |
| 3/28/2010 | 1:05 PM | Orioles at Blue Jays | Dunedin Stadium |
| 3/29/2010 | 7:05 PM | Yankees at Orioles | Ed Smith Stadium |
| 3/30/2010 | 1:05 PM | Tigers at Orioles | Ed Smith Stadium |
| 3/31/2010 | 1:05 PM | Red Sox at Orioles | Ed Smith Stadium |
| 4/1/2010 | 1:05 PM | Orioles at Rays | Charlotte County Stadium |
| 4/2/2010 | 1:05 PM | Orioles at Yankees | George M. Steinbrenner Field |
| 4/3/2010 | 1:05 PM | Mets at Orioles | Ed Smith Stadium |
| Regular Season Begins | |||
| 4/6/2010 | 7:10 PM | Orioles at Rays | Tropicana Field |
| 4/7/2010 | 7:10 PM | Orioles at Rays | Tropicana Field |
| 4/8/2010 | 7:10 PM | Orioles at Rays | Tropicana Field |
| 4/9/2010 | 3:05 PM | Blue Jays at Orioles | Oriole Park at Camden Yards |
| 4/10/2010 | 7:05 PM | Blue Jays at Orioles | Oriole Park at Camden Yards |
| 4/11/2010 | 1:35 PM | Blue Jays at Orioles | Oriole Park at Camden Yards |
| 4/12/2010 | 7:05 PM | Rays at Orioles | Oriole Park at Camden Yards |
| 4/13/2010 | 7:05 PM | Rays at Orioles | Oriole Park at Camden Yards |
| 4/14/2010 | 1:35 PM | Rays at Orioles | Oriole Park at Camden Yards |
| 4/15/2010 | 10:05 PM | Orioles at Athletics | Oakland Coliseum |
| 4/16/2010 | 10:05 PM | Orioles at Athletics | Oakland Coliseum |
| 4/17/2010 | 4:05 PM | Orioles at Athletics | Oakland Coliseum |
| 4/18/2010 | 4:05 PM | Orioles at Athletics | Oakland Coliseum |
| 4/19/2010 | 10:10 PM | Orioles at Mariners | Safeco Field |
| 4/20/2010 | 10:10 PM | Orioles at Mariners | Safeco Field |
| 4/21/2010 | 10:10 PM | Orioles at Mariners | Safeco Field |
| 4/23/2010 | 7:10 PM | Orioles at Red Sox | Fenway Park |
| 4/24/2010 | 7:10 PM | Orioles at Red Sox | Fenway Park |
| 4/25/2010 | 1:35 PM | Orioles at Red Sox | Fenway Park |
| 4/27/2010 | 7:05 PM | Yankees at Orioles | Oriole Park at Camden Yards |
| 4/28/2010 | 7:05 PM | Yankees at Orioles | Oriole Park at Camden Yards |
| 4/29/2010 | 7:05 PM | Yankees at Orioles | Oriole Park at Camden Yards |
| 4/30/2010 | 7:05 PM | Red Sox at Orioles | Oriole Park at Camden Yards |
| 5/1/2010 | 7:05 PM | Red Sox at Orioles | Oriole Park at Camden Yards |
| 5/2/2010 | 1:35 PM | Red Sox at Orioles | Oriole Park at Camden Yards |
| 5/3/2010 | 7:05 PM | Orioles at Yankees | Yankee Stadium |
| 5/4/2010 | 7:05 PM | Orioles at Yankees | Yankee Stadium |
| 5/5/2010 | 3:33 AM | Orioles at Yankees | Yankee Stadium |
| 5/6/2010 | 8:10 PM | Orioles at Twins | Target Field |
| 5/7/2010 | 8:10 PM | Orioles at Twins | Target Field |
| 5/8/2010 | 1:10 PM | Orioles at Twins | Target Field |
| 5/9/2010 | 2:10 PM | Orioles at Twins | Target Field |
| 5/11/2010 | 7:05 PM | Mariners at Orioles | Oriole Park at Camden Yards |
| 5/12/2010 | 7:05 PM | Mariners at Orioles | Oriole Park at Camden Yards |
| 5/13/2010 | 12:35 PM | Mariners at Orioles | Oriole Park at Camden Yards |
| 5/14/2010 | 7:05 PM | Indians at Orioles | Oriole Park at Camden Yards |
| 5/15/2010 | 7:05 PM | Indians at Orioles | Oriole Park at Camden Yards |
| 5/16/2010 | 1:35 PM | Indians at Orioles | Oriole Park at Camden Yards |
| 5/17/2010 | 7:05 PM | Royals at Orioles | Oriole Park at Camden Yards |
| 5/18/2010 | 7:05 PM | Royals at Orioles | Oriole Park at Camden Yards |
| 5/19/2010 | 8:05 PM | Orioles at Rangers | Rangers Ballpark in Arlington |
| 5/20/2010 | 8:05 PM | Orioles at Rangers | Rangers Ballpark in Arlington |
| 5/21/2010 | 7:05 PM | Orioles at Nationals | Nationals Park |
| 5/22/2010 | 4:05 PM | Orioles at Nationals | Nationals Park |
| 5/23/2010 | 1:35 PM | Orioles at Nationals | Nationals Park |
| 5/25/2010 | 7:05 PM | Athletics at Orioles | Oriole Park at Camden Yards |
| 5/26/2010 | 7:05 PM | Athletics at Orioles | Oriole Park at Camden Yards |
| 5/27/2010 | 7:05 PM | Athletics at Orioles | Oriole Park at Camden Yards |
| 5/28/2010 | 7:07 PM | Orioles at Blue Jays | Rogers Centre |
| 5/29/2010 | 1:07 PM | Orioles at Blue Jays | Rogers Centre |
| 5/30/2010 | 1:07 PM | Orioles at Blue Jays | Rogers Centre |
| 6/1/2010 | 7:05 PM | Orioles at Yankees | Yankee Stadium |
| 6/2/2010 | 7:05 PM | Orioles at Yankees | Yankee Stadium |
| 6/3/2010 | 1:05 PM | Orioles at Yankees | Yankee Stadium |
| 6/4/2010 | 7:05 PM | Red Sox at Orioles | Oriole Park at Camden Yards |
| 6/5/2010 | 7:05 PM | Red Sox at Orioles | Oriole Park at Camden Yards |
| 6/6/2010 | 1:35 PM | Red Sox at Orioles | Oriole Park at Camden Yards |
| 6/8/2010 | 7:05 PM | Yankees at Orioles | Oriole Park at Camden Yards |
| 6/9/2010 | 7:05 PM | Yankees at Orioles | Oriole Park at Camden Yards |
| 6/10/2010 | 7:05 PM | Yankees at Orioles | Oriole Park at Camden Yards |
| 6/11/2010 | 7:05 PM | Mets at Orioles | Oriole Park at Camden Yards |
| 6/12/2010 | 7:05 PM | Mets at Orioles | Oriole Park at Camden Yards |
| 6/13/2010 | 1:35 PM | Mets at Orioles | Oriole Park at Camden Yards |
| 6/14/2010 | 10:15 PM | Orioles at Giants | AT&T Park |
| 6/15/2010 | 10:15 PM | Orioles at Giants | AT&T Park |
| 6/16/2010 | 3:45 PM | Orioles at Giants | AT&T Park |
| 6/18/2010 | 10:05 PM | Orioles at Padres | PETCO Park |
| 6/19/2010 | 8:35 PM | Orioles at Padres | PETCO Park |
| 6/20/2010 | 4:05 PM | Orioles at Padres | PETCO Park |
| 6/22/2010 | 7:05 PM | Marlins at Orioles | Oriole Park at Camden Yards |
| 6/23/2010 | 7:05 PM | Marlins at Orioles | Oriole Park at Camden Yards |
| 6/24/2010 | 7:05 PM | Marlins at Orioles | Oriole Park at Camden Yards |
| 6/25/2010 | 7:05 PM | Nationals at Orioles | Oriole Park at Camden Yards |
| 6/26/2010 | 3:33 AM | Nationals at Orioles | Oriole Park at Camden Yards |
| 6/27/2010 | 1:35 PM | Nationals at Orioles | Oriole Park at Camden Yards |
| 6/29/2010 | 7:05 PM | Athletics at Orioles | Oriole Park at Camden Yards |
| 6/30/2010 | 7:05 PM | Athletics at Orioles | Oriole Park at Camden Yards |
| 7/1/2010 | 7:05 PM | Athletics at Orioles | Oriole Park at Camden Yards |
| 7/2/2010 | 7:10 PM | Orioles at Red Sox | Fenway Park |
| 7/3/2010 | 7:10 PM | Orioles at Red Sox | Fenway Park |
| 7/4/2010 | 1:35 PM | Orioles at Red Sox | Fenway Park |
| 7/5/2010 | 3:33 AM | Orioles at Tigers | Comerica Park |
| 7/6/2010 | 7:05 PM | Orioles at Tigers | Comerica Park |
| 7/7/2010 | 7:05 PM | Orioles at Tigers | Comerica Park |
| 7/8/2010 | 8:05 PM | Orioles at Rangers | Rangers Ballpark in Arlington |
| 7/9/2010 | 8:05 PM | Orioles at Rangers | Rangers Ballpark in Arlington |
| 7/10/2010 | 8:05 PM | Orioles at Rangers | Rangers Ballpark in Arlington |
| 7/11/2010 | 3:05 PM | Orioles at Rangers | Rangers Ballpark in Arlington |
| 7/13/2010 | 3:33 AM | NL All-Stars at AL All-Stars |
Angel Stadium of Anaheim |
| 7/16/2010 | 7:05 PM | Blue Jays at Orioles | Oriole Park at Camden Yards |
| 7/17/2010 | 7:05 PM | Blue Jays at Orioles | Oriole Park at Camden Yards |
| 7/18/2010 | 1:35 PM | Blue Jays at Orioles | Oriole Park at Camden Yards |
| 7/19/2010 | 7:05 PM | Rays at Orioles | Oriole Park at Camden Yards |
| 7/20/2010 | 7:05 PM | Rays at Orioles | Oriole Park at Camden Yards |
| 7/21/2010 | 12:35 PM | Rays at Orioles | Oriole Park at Camden Yards |
| 7/22/2010 | 7:05 PM | Twins at Orioles | Oriole Park at Camden Yards |
| 7/23/2010 | 7:05 PM | Twins at Orioles | Oriole Park at Camden Yards |
| 7/24/2010 | 4:10 PM | Twins at Orioles | Oriole Park at Camden Yards |
| 7/25/2010 | 1:35 PM | Twins at Orioles | Oriole Park at Camden Yards |
| 7/26/2010 | 7:07 PM | Orioles at Blue Jays | Rogers Centre |
| 7/27/2010 | 7:07 PM | Orioles at Blue Jays | Rogers Centre |
| 7/28/2010 | 7:07 PM | Orioles at Blue Jays | Rogers Centre |
| 7/29/2010 | 8:10 PM | Orioles at Royals | Kauffman Stadium |
| 7/30/2010 | 8:10 PM | Orioles at Royals | Kauffman Stadium |
| 7/31/2010 | 7:10 PM | Orioles at Royals | Kauffman Stadium |
| 8/1/2010 | 2:10 PM | Orioles at Royals | Kauffman Stadium |
| 8/3/2010 | 7:05 PM | Angels at Orioles | Oriole Park at Camden Yards |
| 8/4/2010 | 7:05 PM | Angels at Orioles | Oriole Park at Camden Yards |
| 8/5/2010 | 7:05 PM | Angels at Orioles | Oriole Park at Camden Yards |
| 8/6/2010 | 7:05 PM | White Sox at Orioles | Oriole Park at Camden Yards |
| 8/7/2010 | 7:05 PM | White Sox at Orioles | Oriole Park at Camden Yards |
| 8/8/2010 | 1:35 PM | White Sox at Orioles | Oriole Park at Camden Yards |
| 8/9/2010 | 7:05 PM | White Sox at Orioles | Oriole Park at Camden Yards |
| 8/10/2010 | 7:05 PM | Orioles at Indians | Progressive Field |
| 8/11/2010 | 7:05 PM | Orioles at Indians | Progressive Field |
| 8/12/2010 | 7:05 PM | Orioles at Indians | Progressive Field |
| 8/13/2010 | 7:10 PM | Orioles at Rays | Tropicana Field |
| 8/14/2010 | 4:10 PM | Orioles at Rays | Tropicana Field |
| 8/15/2010 | 1:40 PM | Orioles at Rays | Tropicana Field |
| 8/16/2010 | 7:05 PM | Mariners at Orioles | Oriole Park at Camden Yards |
| 8/17/2010 | 7:05 PM | Mariners at Orioles | Oriole Park at Camden Yards |
| 8/18/2010 | 7:05 PM | Mariners at Orioles | Oriole Park at Camden Yards |
| 8/19/2010 | 7:05 PM | Rangers at Orioles | Oriole Park at Camden Yards |
| 8/20/2010 | 7:05 PM | Rangers at Orioles | Oriole Park at Camden Yards |
| 8/21/2010 | 4:10 PM | Rangers at Orioles | Oriole Park at Camden Yards |
| 8/22/2010 | 1:35 PM | Rangers at Orioles | Oriole Park at Camden Yards |
| 8/24/2010 | 8:10 PM | Orioles at White Sox | U.S. Cellular Field |
| 8/25/2010 | 8:10 PM | Orioles at White Sox | U.S. Cellular Field |
| 8/26/2010 | 8:10 PM | Orioles at White Sox | U.S. Cellular Field |
| 8/27/2010 | 10:05 PM | Orioles at Angels | Angel Stadium of Anaheim |
| 8/28/2010 | 9:05 PM | Orioles at Angels | Angel Stadium of Anaheim |
| 8/29/2010 | 3:35 PM | Orioles at Angels | Angel Stadium of Anaheim |
| 8/31/2010 | 7:05 PM | Red Sox at Orioles | Oriole Park at Camden Yards |
| 9/1/2010 | 7:05 PM | Red Sox at Orioles | Oriole Park at Camden Yards |
| 9/2/2010 | 7:05 PM | Red Sox at Orioles | Oriole Park at Camden Yards |
| 9/3/2010 | 7:05 PM | Rays at Orioles | Oriole Park at Camden Yards |
| 9/4/2010 | 7:05 PM | Rays at Orioles | Oriole Park at Camden Yards |
| 9/5/2010 | 1:35 PM | Rays at Orioles | Oriole Park at Camden Yards |
| 9/6/2010 | 1:05 PM | Orioles at Yankees | Yankee Stadium |
| 9/7/2010 | 7:05 PM | Orioles at Yankees | Yankee Stadium |
| 9/8/2010 | 1:05 PM | Orioles at Yankees | Yankee Stadium |
| 9/10/2010 | 7:05 PM | Orioles at Tigers | Comerica Park |
| 9/11/2010 | 7:05 PM | Orioles at Tigers | Comerica Park |
| 9/12/2010 | 1:05 PM | Orioles at Tigers | Comerica Park |
| 9/13/2010 | 7:05 PM | Blue Jays at Orioles | Oriole Park at Camden Yards |
| 9/14/2010 | 7:05 PM | Blue Jays at Orioles | Oriole Park at Camden Yards |
| 9/15/2010 | 7:05 PM | Blue Jays at Orioles | Oriole Park at Camden Yards |
| 9/17/2010 | 7:05 PM | Yankees at Orioles | Oriole Park at Camden Yards |
| 9/18/2010 | 7:05 PM | Yankees at Orioles | Oriole Park at Camden Yards |
| 9/19/2010 | 1:35 PM | Yankees at Orioles | Oriole Park at Camden Yards |
| 9/20/2010 | 7:10 PM | Orioles at Red Sox | Fenway Park |
| 9/21/2010 | 7:10 PM | Orioles at Red Sox | Fenway Park |
| 9/22/2010 | 7:10 PM | Orioles at Red Sox | Fenway Park |
| 9/24/2010 | 7:07 PM | Orioles at Blue Jays | Rogers Centre |
| 9/25/2010 | 1:07 PM | Orioles at Blue Jays | Rogers Centre |
| 9/26/2010 | 1:07 PM | Orioles at Blue Jays | Rogers Centre |
| 9/27/2010 | 7:10 PM | Orioles at Rays | Tropicana Field |
| 9/28/2010 | 7:10 PM | Orioles at Rays | Tropicana Field |
| 9/29/2010 | 7:10 PM | Orioles at Rays | Tropicana Field |
| 9/30/2010 | 7:05 PM | Tigers at Orioles | Oriole Park at Camden Yards |
| 10/1/2010 | 7:05 PM | Tigers at Orioles | Oriole Park at Camden Yards |
| 10/2/2010 | 7:05 PM | Tigers at Orioles | Oriole Park at Camden Yards |
| 10/3/2010 | 1:35 PM | Tigers at Orioles | Oriole Park at Camden Yards |
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